Aricept Side Effects & Drug Interactions

Drug Library
Aricept - Side Effects & Drug Interactions [donepezil hydrochloride]

Respiratory System:

Frequent: dyspnea, sore throat, bronchitis;
Infrequent: epistaxis, post nasal drip, pneumonia, hyperventilation, pulmonary congestion, wheezing, hypoxia, pharyngitis, pleurisy, pulmonary collapse, sleep apnea, snoring.

Skin and Appendages:

Frequent: pruritus, diaphoresis, urticaria;
Infrequent: dermatitis, erythema, skin discoloration, hyperkeratosis, alopecia, fungal dermatitis, herpes zoster, hirsutism, skin striae, night sweats, skin ulcer.

Special Senses:

Frequent: cataract, eye irritation, vision blurred;
Infrequent: dry eyes, glaucoma, earache, tinnitus, blepharitis, decreased hearing, retinal hemorrhage, otitis externa, otitis media, bad taste, conjunctival hemorrhage, ear buzzing, motion sickness, spots before eyes.

Urogenital System:

Frequent: urinary incontinence, nocturia;
Infrequent: dysuria, hematuria, urinary urgency, metrorrhagia, cystitis, enuresis, prostate hypertrophy, pyelonephritis, inability to empty bladder, breast fibroadenosis, fibrocystic breast, mastitis, pyuria, renal failure, vaginitis.

Postintroduction Reports

Voluntary reports of adverse events temporally associated with ARICEPTŽ that have been received since market introduction that are not listed above, and that there is inadequate data to determine the causal relationship with the drug include the following: abdominal pain, agitation, cholecystitis, confusion, convulsions, hallucinations, heart block (all types), hemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, and rash.

Drug-Drug Interactions

Drugs Highly Bound to Plasma Proteins:

Drug displacement studies have been performed in vitro between this highly bound drug (96%) and other drugs such as furosemide, digoxin, and warfarin. ARICEPTŽ at concentrations of 0.3-10 mg/mL did not affect the binding of furosemide (5 mg/mL), digoxin (2 ng/mL), and warfarin (3 mg/mL) to human albumin. Similarly, the binding of ARICEPTŽ to human albumin was not affected by furosemide, digoxin and warfarin.