DOSAGE AND ADMINISTRATION
Since both the Augmentin 250 mg and 500 mg tablets contain the same amount of clavulanic acid (125 mg, as the potassium salt), 2 Augmentin 250 mg tablets are not equivalent to 1 Augmentin 500 mg tablet. Therefore, 2 Augmentin 250 mg tablets should not be substituted for 1 Augmentin 500 mg tablet.
The usual adult dose is 1 Augmentin 500 mg tablet every 12 hours or 1 Augmentin 250 mg tablet every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be 1 Augmentin 875 mg tablet every 12 hours or 1 Augmentin 500 mg tablet every 8 hours.
Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe. Severely impaired patients with a glomerular filtration rate of <30 mL/ minute should not receive the 875 mg tablet.
Patients with a glomerular filtration rate of 10 to 30 mL/ minute should receive 500 mg or 250 mg every 12 hours, depending on the severity of the infection. Patients with a less than 10 mL/ minute glomerular filtration rate should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection.
Hemodialysis patients should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis. Hepatically impaired patients should be dosed with caution and hepatic function monitored at regular intervals. (See WARNINGS.)
Pediatric patients weighing 40 kg or more should be dosed according to the adult recommendations. Due to the different amoxicillin to clavulanic acid ratios in the Augmentin 250 mg tablet (250/ 125) versus the Augmentin 250 mg chewable tablet (250/ 62.5), the Augmentin 250 mg tablet should not be used until the pediatric patient weighs at least 40 kg or more.