Cialis - Overdosage & Contraindications

CONTRAINDICATIONS

Nitrates — Administration of CIALIS to patients who are using any form of organic nitrate, either regularly and/ or intermittently, is contraindicated. In clinical pharmacology studies, tadalafil was shown to potentiate the hypotensive effect of nitrates. This is thought to result from the combined effects of nitrates and tadalafil on the nitric oxide/ cGMP pathway (see Pharmacodynamics, Effects on Blood Pressure when CIALIS is Administered

with Nitrates under CLINICAL PHARMACOLOGY).

Alpha Blockers — Administration of CIALIS to patients taking any alpha-adrenergic antagonist other than 0.4 mg once-daily tamsulosin is contraindicated. In a drug-drug interaction study, when tadalafil 20 mg was administered to healthy subjects taking doxazosin (8 mg daily), there was a significant augmentation of the blood-pressure-lowering effect of doxazosin (see Drug Interactions under PRECAUTIONS).

Hypersensitivity —

CIALIS is contraindicated for patients with a known hypersensitivity to tadalafil or any component of the tablet.

OVERDOSAGE

Single doses up to 500 mg have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients. Adverse events were similar to those seen at lower doses. In cases of overdose, standard supportive measures should be adopted as required. Hemodialysis contributes negligibly to tadalafil elimination.