Amlodipine ? A study was conducted to assess the interaction of amlodipine (5 mg daily) and tadalafil 10 mg. There was no effect of tadalafil on amlodipine blood levels and no effect of amlodipine on tadalafil blood levels. The mean reduction in supine systolic/ diastolic blood pressure due to tadalafil 10 mg in subjects taking amlodipine was 3/ 2 mm Hg, compared to placebo. In a similar study using tadalafil 20 mg, there were no clinically significant differences between tadalafil and placebo in subjects taking amlodipine. Metoprolol ? A study was conducted to assess the interaction of sustained-release metoprolol (25 to 200 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/ diastolic blood pressure due to tadalafil 10 mg in subjects taking metoprolol was 5/ 3 mm Hg, compared to placebo. Bendrofluazide ? A study was conducted to assess the interaction of bendrofluazide (2.5 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/ diastolic blood pressure due to tadalafil 10 mg in subjects taking bendrofluazide was 6/ 4 mm Hg, compared to placebo. Enalapril ? A study was conducted to assess the interaction of enalapril (10 to 20 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/ diastolic blood pressure due to tadalafil 10 mg in subjects taking enalapril was 4/ 1 mm Hg, compared to placebo. Angiotensin II receptor blocker (and other anti-hypertensives) ? A study was conducted to assess the interaction of angiotensin II receptor blockers and tadalafil 20 mg. Subjects in the study were taking any marketed angiotensin II receptor blocker, either alone, as a component of a combination product, or as part of a multiple anti-hypertensive regimen. Following dosing, ambulatory measurements of blood pressure revealed differences between tadalafil and placebo of 8/ 4 mm Hg in systolic/ diastolic blood pressure. | ||||
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