DESCRIPTION Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate. Tamsulosin HCl is (-)-( R)-5-[ 2-[[ 2-( 0-ethoxyphenoxy) ethyl] amino] propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin HCl occurs as white crystals that melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether. The empirical formula of tamsulosin HCl is C20H28N2O5S . HCl. The molecular weight of tamsulosin HCl is 444.98. Each FLOMAX capsule for oral administration contains tamsulosin HCl 0.4 mg, and the following inactive ingredients: methacrylic acid copolymer, microcrystalline cellulose, triacetin, polysorbate 80, sodium lauryl sulfate, calcium stearate, talc, FD& C blue No. 2, titanium dioxide, ferric oxide, gelatin, and trace amounts of shellac, industrial methylated spirit 74 OP, n-butyl, alcohol, isopropyl alcohol, propylene glycol, dimethylpolysiloxane, and black iron oxide E172. | ||||
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