Ear, Nose, and Throat Aphonia, facial and oropharyngeal edema, hoarseness, laryngitis, and throat soreness and irritation. Endocrine and Metabolic Cushingoid features, growth velocity reduction in children/ adolescents, hyperglycemia, osteoporosis, and weight gain. Eye Cataracts. Non-Site Specific Very rare anaphylactic reaction. Psychiatry: Agitation, aggression, depression, and restlessness. Respiratory Asthma exacerbation, bronchospasm, chest tightness, cough, dyspnea, immediate bronchospasm, paradoxical bronchospasm, pneumonia, and wheeze. Skin Contusions, cutaneous hypersensitivity reactions, ecchymoses, and pruritus. Eosinophilic Conditions: In rare cases, patients on inhaled fluticasone propionate may present with systemic eosinophilic conditions, with some patients presenting with clinical features of vasculitis consistent with Churg-Strauss syndrome, a condition that is often treated with systemic corticosteroid therapy. These events usually, but not always, have been associated with the reduction and/ or withdrawal of oral corticosteroid therapy following the introduction of fluticasone propionate. Cases of serious eosinophilic conditions have also been reported with other inhaled corticosteroids in this clinical setting. Physicians should be alert to eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, and/ or neuropathy presenting in their patients. A causal relationship between fluticasone propionate and these underlying conditions has not been established (see PRECAUTIONS: Eosinophilic Conditions). | ||||
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