Levaquin Clinical Pharmacology

Drug Library
Levaquin - Clinical Pharmacology [Levofloxacin]

Multiple dose
500 mg q24h p. o. 3 5.7 ą 1.4 1.1 ą 0. 4 47.5 ą 6. 7 175 ą 25 102 ą 22 7.6 ą 1. 6 116 ą 31
500 mg q24h i. v. 3 6.4 ą 0. 8 ND 54.6 ą 11.1 158 ą 29 91 ą 12 7.0 ą 0. 8 99 ą 28
500 mg or 250 mg q24h i. v., 8.7 ą 4. 0 7 ND 72.5 ą 51.2 7 154 ą 72 111 ą 58 ND ND
patients with bacterial infection 6
750 mg q24h p. o. 5 8.6 ą 1. 9 1.4 ą 0. 5 90.7 ą 17.6 143 ą 29 100 ą 16 8.8 ą 1. 5 116 ą 28
750 mg q24h i. v. 5 12.1 ą 4. 1 4 ND 108 ą 34 126 ą 37 80 ą 27 7.9 ą 1. 9 ND
500 mg p. o. single dose, effects of gender and age:
Male 8 5.5 ą 1. 1 1.2 ą 0. 4 54.4 ą 18.9 166 ą 44 89 ą 13 7.5 ą 2. 1 126 ą 38
Female 9 7.0 ą 1. 6 1.7 ą 0. 5 67.7 ą 24.2 136 ą 44 62 ą 16 6.1 ą 0. 8 106 ą 40
Young 10 5.5 ą 1. 0 1.5 ą 0. 6 47.5 ą 9. 8 182 ą 35 83 ą 18 6.0 ą 0. 9 140 ą 33
Elderly 11 7.0 ą 1. 6 1.4 ą 0. 5 74.7 ą 23.3 121 ą 33 67 ą 19 7.6 ą 2. 0 91 ą 29

500 mg p. o. single dose, patients with renal insufficiency:
CLCR 50-80 mL/ min 7.5 ą 1. 8 1.5 ą 0. 5 95.6 ą 11.8 88 ą 10 ND 9.1 ą 0. 9 57 ą 8
CLCR 20-49 mL/ min 7.1 ą 3. 1 2.1 ą 1. 3 182.1 ą 62.6 51 ą 19 ND 27 ą 10 26 ą 13
CLCR <20 mL/ min 8.2 ą 2. 6 1.1 ą 1. 0 263.5 ą 72.5 33 ą 8 ND 35 ą 5 13 ą 3
Hemodialysis 5.7 ą 1. 0 2.8 ą 2. 2 ND ND ND 76 ą 42 ND
CAPD 6.9 ą 2. 3 1.4 ą 1. 1 ND ND ND 51 ą 24 ND

1 clearance/ bioavailability

2 volume of distribution/ bioavailability

3 healthy males 18-53 years of age

4 60 min infusion for 250 mg and 500 mg doses, 90 min infusion for 750 mg dose

5 healthy male and female subjects
18-54 years of age

6 500 mg q48h for patients with moderate renal impairment (CLCR 20-50 mL/ min) and infections of the respiratory tract or skin

7 dose-normalized values (to 500 mg
dose), estimated by population pharmacokinetic modeling

8 healthy males 22-75 years of age

9 healthy females 18-80 years of age

10 young healthy male and female subjects 18-36 years of age 11 healthy elderly male and female subjects 66-80 years of age *Absolute bioavailability; F = 0.99 ą 0.08 from a 500-mg tablet and F= 0.99 ą 0.06 from a 750-mg tablet; ND = not determined.