Levaquin Indications & Dosage

Drug Library
Levaquin - Indications & Dosage [Levofloxacin]

Patients with Impaired Renal Function Renal Status Initial Dose Subsequent Dose
Acute Bacterial Exacerbation of Chronic Bronchitis / Comm. Acquired Pneumonia / Acute Maxillary Sinusitis /
Uncomplicated SSSI/ Chronic Bacterial Prostatitis CLCR from 50 to 80 mL/ min No dosage adjustment required
CLCR from 20 to 49 mL/ min 500 mg 250 mg q24h CLCR from 10 to 19 mL/ min 500 mg 250 mg q48h
Hemodialysis 500 mg 250 mg q48h CAPD 500 mg 250 mg q48h

Complicated SSSI/ Nosocomial Pneumonia/ Comm. Acquired Pneumonia
CLCR from 50 to 80 mL/ min No dosage adjustment required CLCR from 20 to 49 mL/ min 750 mg 750 mg q48h
CLCR from 10 to 19 mL/ min 750 mg 500 mg q48h Hemodialysis 750 mg 500 mg q48h
CAPD 750 mg 500 mg q48h
Complicated UTI / Acute Pyelonephritis CLCR 20 mL/ min No dosage adjustment required

CLCR from 10 to 19 mL/ min 250 mg 250 mg q48h
Uncomplicated UTI No dosage adjustment required CLCR =creatinine clearances

CAPD= chronic ambulatory peritoneal dialysis
When only the serum creatinine is known, the following formula may be
used to estimate creatinine clearance.

Men: Creatinine Clearance (mL/ min) =
Weight (kg) x (140 Ð age)
72 x serum creatinine (mg/ dL)
Women: 0.85 x the value calculated for men.

The serum creatinine should represent a steady state of renal function.
Preparation of Levofloxacin Injection for Administration LEVAQUIN Injection in Single-Use Vials: LEVAQUIN Injection is sup-plied in single-use vials containing a concentrated levofloxacin solution with the equivalent of 500 mg (20 mL vial) and 750 mg (30 mL vial) of levofloxacin in Water for Injection, USP. The 20 mL and 30 mL vials each contain 25 mg of levofloxacin/ mL.

THESE LEVAQUIN INJECTION SINGLE-USE VIALS MUST BE FURTHER DILUTED WITH AN APPROPRIATE SOLUTION PRIOR TO INTRAVENOUS ADMINISTRATION. (See COMPATIBLE INTRAVENOUS SOLUTIONS.) The concentration of the resulting diluted solution should be 5 mg/ mL prior to administration.