Levaquin Indications & Dosage

Drug Library
Levaquin - Indications & Dosage [Levofloxacin]

This intravenous drug product should be inspected visually for particu-late matter prior to administration. Samples containing visible particles should be discarded. Since no preservative or bacteriostatic agent is present in this product, aseptic technique must be used in preparation of the final intravenous solution. Since the vials are for single-use only, any unused portion remaining in the vial should be discarded. When used to prepare two 250 mg doses from the 20 mL vial containing 500 mg of levofloxacin, the full content of the vial should be withdrawn at once using a single-entry procedure, and a second dose should be prepared and stored for subsequent use. (See Stability of LEVAQUIN Injection Following Dilution.)

Since only limited data are available on the compatibility of levofloxacin intravenous injection with other intravenous substances, additives or other medications should not be added to LEVAQUIN Injection in single-use vials or infused simultaneously through the same intravenous line. If the same intravenous line is used for sequential infusion of several different drugs, the line should be flushed before and after infusion of LEVAQUIN Injection with an infusion solution compati-ble with LEVAQUIN Injection and with any other drug( s) administered via this common line.

Prepare the desired dosage of levofloxacin according to the following chart:
Desired From Appropriate Vial, Volume of Infusion Dosage Strength Withdraw Volume Diluent Time
250 mg 10 mL (20 mL Vial) 40 mL 60 min
500 mg 20 mL (20 mL Vial) 80 mL 60 min
750 mg 30 mL (30 mL Vial) 120 mL 90 min
For example, to prepare a 500 mg dose using the 20 mL vial (25 mg/ mL), withdraw 20 mL and dilute with a compatible intravenous solution to a

total volume of 100 mL.
Compatible Intravenous Solutions: Any of the following intravenous solutions may be used to prepare a 5 mg/ mL levofloxacin solution with the approximate pH values:
Final pH of Intravenous Fluids LEVAQUIN Solution