In patients who are currently being treated with a diuretic, symptomatic hypotension occasionally can occur following the initial dose of Lotensin. To reduce the likelihood of hypotension, the diuretic should, if possible, be discontinued two to three days prior to beginning therapy with Lotensin (see WARNINGS). Then, if blood pressure is not controlled with Lotensin alone, diuretic therapy should be resumed. If the diuretic cannot be discontinued, an initial dose of 5 mg Lotensin should be used to avoid excessive hypotension. Dosage Adjustment in Renal Impairment For patients with a creatinine clearance < 30 mL/ min/ 1.73 m 2 (serum creatinine > 3 mg/ dL), the recommended initial dose is 5 mg Lotensin once daily. Dosage may be titrated upward until blood pressure is controlled or to a maximum total daily dose of 40 mg (see WARNINGS). HOW SUPPLIED Lotensin is available in tablets of 5 mg, 10 mg, 20 mg, and 40 mg, packaged with a desiccant in bottles of 90 and 100 tablets. Lotensin is also supplied in blister packages (1 tablet/ blister), in Accu-Pak ® Unit Dose boxes containing 10 strips of 10 blisters each. Each tablet is imprinted with LOTENSIN on one side and the tablet strength (" 5," "10," "20," or "40") on the other. The National Drug Codes for the various packages are Tablet Dose Color Bottle of 90 Bottle of 100 Accu-Pak ® of 100 5 mg light yellow NDC 0083-0059-90 NDC 0083-0059-30 NDC 0083-0059-32 10 mg dark yellow NDC 0083-0063-90 NDC 0083-0063-30 NDC 0083-0063-32 20 mg pink NDC 0083-0079-90 NDC 0083-0079-30 NDC 0083-0079-32 40 mg dark rose NDC 0083-0094-90 NDC 0083-0094-30 NDC 0083-0094-32 Storage: Do not store above 30° C (86° F). Protect from moisture. Dispense in tight container (USP). T2002-06 REV: JANUARY 2002 Printed in U. S. A. 89008505 Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936 ©2002 Novartis | ||||
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