DESCRIPTION Benazepril hydrochloride is a white to off-white crystalline powder, soluble (> 100 mg/ mL) in water, in ethanol, and in methanol. Benazepril's chemical name is 3-[[ 1-( ethoxy-carbonyl)-3-phenyl-( 1S)-propyl] amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-( 3S)-benzazepine-1-acetic acid monohydrochloride. Its empirical formula is C24H28N2O5 HCl, and its molecular weight is 460.96. Benazeprilat, the active metabolite of benazepril, is a non-sulfhydryl angiotensin-converting enzyme inhibitor. Benazepril is converted to benazeprilat by hepatic cleavage of the ester group. Lotensin is supplied as tablets containing 5 mg, 10 mg, 20 mg, and 40 mg of benazepril hydrochloride for oral administration. The inactive ingredients are cellulose compounds, colloidal silicon dioxide, crospovidone, hydrogenated castor oil (5-mg, 10-mg, and 20-mg tablets), iron oxides, lactose, magnesium stearate (40-mg tablets), polysorbate 80, propylene glycol (5-mg and 40-mg tablets), starch, talc, and titanium dioxide. | ||||
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