MONOPRIL (fosinopril sodium tablets) is the sodium salt of fosinopril, the ester pro-drug of an angiotensin-converting enzyme (ACE) inhibitor, fosinoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin-converting enzyme. Fosinopril sodium is designated chemically as: L-proline, 4-cyclohexyl-1-[[[ 2-methyl-1-( 1-oxopropoxy) propoxy]( 4-phenylbutyl) phosphinyl] acetyl]-, sodium salt, trans-. Fosinopril sodium is a white to off-white crystalline powder. It is soluble in water (100 mg/ mL), methanol, and ethanol and slightly soluble in hexane.
Its empirical formula is C 30 H 45 NNaO 7 P, and its molecular weight is 585.65. MONOPRIL is available for oral administration as 10 mg, 20 mg, and 40 mg tablets. Inactive ingredients include: lactose, microcrystalline cellulose, crospovidone, povidone, and sodium stearyl fumarate.