Plavix Side Effects & Drug Interactions

Drug Library
Plavix - Side Effects & Drug Interactions [Clopidogrel]

Red blood cell disorders

Anemia aplastic, anemia hypochromic.

Reproductive disorders, female

Menorrhagia.

Respiratory system disorders

Hemothorax.

Skin and appendage disorders

Bullous eruption, rash erythematous, rash maculopapular, urticaria.

Urinary system disorders

Abnormal renal function, acute renal failure.

White cell and reticuloendothelial system disorders

Agranulocytosis, granulocytopenia, leukemia, leukopenia, neutrophils decreased.

Postmarketing Experience
The following events have been reported spontaneously from worldwide postmarketing experience:

Body as a whole:

hypersensitivity reactions, anaphylactoid reactions

Central and Peripheral Nervous System disorders:

confusion, hallucinations, taste disorders

Liver and Biliary system disorders:

abnormal liver function test, hepatitis (non-infectious)

Platelet, Bleeding and Clotting disorders:

cases of bleeding with fatal outcome (especially intracranial, gastrointestinal and retroperitoneal hemorrhage)

agranulocytosis, aplastic anemia/pancytopenia, thrombotic thrombocytopenic purpura (TTP) - see WARNINGS.

conjunctival, ocular and retinal bleeding

Respiratory system disorders:

bronchospasm

Skin and Appendage disorders:

angioedema, erythema multiforme

Urinary system disorders:
glomerulopathy, abnormal creatinine levels

Drug Interactions

Study of specific drug interactions yielded the following results:

Aspirin

Aspirin did not modify the clopidogrel-mediated inhibition of ADP-induced platelet aggregation. Concomitant administration of 500 mg of aspirin twice a day for 1 day did not significantly increase the prolongation of bleeding time induced by PLAVIX. PLAVIX potentiated the effect of aspirin on collagen-induced platelet aggregation. PLAVIX and aspirin have been administered together for up to one year.

Heparin

In a study in healthy volunteers, PLAVIX did not necessitate modification of the heparin dose or alter the effect of heparin on coagulation. Coadministration of heparin had no effect on inhibition of platelet aggregation induced by PLAVIX.