Wegener?s granulomatosis

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Adenocarcinoma - chest X-ray

Wegener's granulomatosis on the leg

Wegener?s granulomatosis

Alternative Names:

Midline granulomatosis
Symptoms:

Frequent sinusitis is the most common symptom. Other early symptoms include persistent fever without an obvious cause,night sweats, fatigue, and malaise (an ill feeling).

Chronic ear infectionsmay alsocome beforethe diagnosis of Wegener's granulomatosis. Other upper respiratory symptoms include nose bleeds, pain, and sores around the opening of the nose.

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Loss of appetite and weight loss are common. Skin lesions typically occur, but there is no onetypical lesion associated with the disease.

Symptoms of kidney disease may be present (but not always). The urine may be bloody, and often first appears as red or smoky urine.

Eye problems develop in a significant number of patients. Theymay range from mild conjunctivitis to severeswelling of the eye.

Other symptoms include:

Weakness
Cough, orcoughing up blood
Bloody sputum
Shortness of breath
Wheezing
Chest pain
Rashes
Joint pains

Signs and tests:
A variety of tests may be performed, including:

Biopsy of abnormal tissue:
- Open lung biopsy
- Upper airway biopsy
- Nasal mucosal biopsy
- Bronchoscopy with transtracheal biopsy
- Kidney biopsy
Urinalysis to look for signs of kidney disease such as protein and blood in the urine. The presence of kidney disease is necessary to make a definitive diagnosis of Wegener's granulomatosis.
Chest x-ray
Bone marrow aspiration
Blood tests to look for antibodies that the body makes against its own tissue.