Primary biliary cirrhosis

Table of Contents

Alternative Names

PBC


Symptoms

More than half of patients have no symptoms at the time of diagnosis. Symptoms usually come on gradually and may include:

  • Abdominal pain
  • Enlarged liver
  • Fatigue
  • Fatty deposits under the skin
  • Fatty stools
  • Itching
  • Jaundice
  • Soft yellow spots on the eyelid

Signs and tests

Tests for liver dysfunction:

  • Serum albumin
  • Liver function tests (serum alkaline phosphatase is most important)
  • Prothrombin time (PT)
  • Serum cholesterol and lipoproteins

Tests for the disease:

  • Elevated immunoglobulin M level in the blood
  • Liver biopsy
  • Anti-mitochondrial antibodies (results are positive in about 95% of cases)


Review Date: 05/04/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)