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Friday, November 21, 2008

Hemochromatosis

Hepatomegaly
Hepatomegaly
Definition

Hemochromatosis is a disorder that interferes with iron metabolism, which results in too much iron in the body.


Causes, incidence, and risk factors

Hemochromatosis occurs when too much iron builds up in the liver. This leads to liver enlargement. The disease may lead to the development of diabetes, skin coloring changes, heart problems, arthritis, testicular atrophy, cirrhosis of the liver, liver cancer, hypopituitarism, chronic abdominal pain, severe fatigue, and an increased risk of certain bacterial infections.

There are two forms of hemochromatosis: primary and secondary.

Primary hemochromatosis is caused by a problem with your genes or by receiving a large number of blood transfusions which boost your iron levels. Primary hemochromatosis is the most common genetic disorder in the United States, affecting an estimated 1 of every 200 to 300 Americans.

Secondary or acquired hemochromatosis can be caused by diseases such as thalassemia or sideroblastic anemia. Occasionally, it may be seen with hemolytic anemia, chronic alcoholism, and other conditions.

Hemochromatosis affects more men than women. It is particularly common in Caucasians of western European descent. Symptoms are often seen in men between the ages of 30 and 50 and in women over 50, although some people may develop problems by age 20. You have a higher risk of hemochromatosis if someone else in your family has or had the condition.



Review Date: 09/22/2006
Reviewed By: William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.

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