Addison?s disease

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Endocrine glands

Overview Symptoms Treatment Prevention

Addison?s disease

• Extreme weakness
• Fatigue
• Unintentional weight loss
• Nausea and vomiting
• Chronic diarrhea
• Loss of appetite
• Darkening of the skin - patchy skin color
  • Unnaturally dark color in some locations
  • Paleness may also occur
• Mouth lesions on the inside of a cheek (buccal mucosa) - pigmentation
• Slow, sluggish, lethargic movement
• Changes in the blood pressure or heart rate
• Salt craving

• Blood pressure is low.
• Cortisol level is low.
• Serum sodium is low.
• A potassium test may show increased potassium.
• An abdominal x-ray may show adrenal calcification.
• An abdominal CT scan may show adrenal calcification, enlargement or atrophy.

• Renin
• Potassium test
• Cortisol, urine
• CO2
• Aldosterone
• ACTH
• 24 hour urinary aldosterone excretion rate
• 17-ketosteroids
• 17-hydroxycorticosteroids
• Cortrosyn stimulation test
• Blood eosinophil count (a special white blood cell)

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