Multiple Endocrine Neoplasia (MEN) I

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Endocrine glands

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Multiple Endocrine Neoplasia (MEN) I

Symptoms vary greatly from person to person and may be related to peptic ulcer disease, hypoglycemia, hypercalcemia, or pituitary dysfunction.

• Abdominal pain
• Burning, aching, or hunger discomfort in the upper abdomen or lower chest that is relieved by antacids, milk, or food
• Black, tarry stools
• Nausea and vomiting
• Bloated feeling after meals
• Weakness
• Headache
• Vision problems
• Loss of coordination
• Anxiety
• Mental changes or confusion
• Coma if hypoglycemia is untreated
• Loss of appetite
• Muscle pain
• Fatigue
• Sensitivity to the cold
• Unintentional weight loss
• Low blood pressure
• Loss of axillary or pubic hair
• In women, cessation of menses, infertility, or failure to lactate
• In men, decreased sexual interest, loss of body or facial hair

Diagnostic tests are used to evaluate the function of each endocrine gland.

Pancreatic evaluation may reveal the following signs:

• MRI of abdomen shows a pancreatic tumor.
• CT of abdomen shows a pancreatic tumor.
• Insulin test may show increased levels.
• Fasting blood sugar may be low.
• Serum glucagon may be elevated.
• Serum gastrin may be elevated.

• Serum calcium level is elevated, and the serum parathyroid hormone is increased.
• Parathyroid biopsy shows tumor or hyperplasia

• Cranial CT scan or MRI of head may reveal a pituitary tumor.

• Serum thyroid stimulating hormone (rarely used)
• Cortisol
• Serum adrenocorticotropic hormone
• Serum luteinizing hormone
• Serum follicle stimulating hormone

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