Saturday, February, 11, 2012

Paget’s disease

Table of Contents

Alternative Names

Osteitis deformans


Symptoms
  • Bone pain (may be severe and persistent)
  • Bowing of the legs and other visible deformities
  • Enlarged head
  • Fracture
  • Headache
  • Hearing loss
  • Joint pain or stiffness
  • Neck pain
  • Reduced height
  • Skull deformities
  • Warmth of skin over the affected bone

Note: Most patients have no symptoms.


Signs and tests

Tests that may indicate Paget's disease include:

  • Bone scan
  • Bone x-ray
  • Elevated markers of bone breakdown (for instance, N-telopeptide)
  • Elevated serum alkaline phosphatase

This disease may also affect the results of the following tests:

  • ALP (alkaline phosphatase) isoenzyme
  • Serum calcium

Images

X-ray

Review Date: 11/23/2009
Reviewed By: Ari S. Eckman, MD. Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)