Membranoproliferative GN I; Membranoproliferative GN II; Mesangiocapillary glomerulonephritis; Membranoproliferative glomerulonephritis; Lobular GN; Glomerulonephritis - membranoproliferative; MPGN type I; MPGN type II

• Blood in the urine
• Dark urine (smoke, cola, or tea colored)
• Cloudy urine
• Decrease in urine volume
• Swelling of any part of the body
• Changes in mental status such as decreased alertness or decreased concentration

The results of a physical examination vary depending on the symptoms. Swelling may be present along with signs of fluid overload, such as abnormal sounds when listening to the heart and lungs with a stethoscope.

Blood pressure is often high because of increased water and sodium (salt) retention and and increased production of renin, a hormone that controls blood pressure.

Membranoproliferative GN may present in several forms. It may be seen as acute nephritic syndrome, nephrotic syndrome, or an abnormal urinalysis without symptoms.

These tests help confirm the diagnosis:

• Urinalysis
• Urine protein
• BUN and creatinine
• Serum complement levels
• Serum complement C3 nephritic factor

A kidney biopsy confirms the diagnosis of membranoproliferative GN I.

Images

Kidney anatomy

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Membranoproliferative GN Overview

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Membranoproliferative GN Treatment

Review Date: 08/12/2009
Reviewed By: Parul Patel, MD, Private Practice specializing in Nephrology and Kidney and Pancreas Transplantation, Affiliated with California Pacific Medical Center, Department of Transplantation, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)