Membranoproliferative GN II

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Kidney anatomy

Membranoproliferative GN II

Alternative Names:

Membranoproliferative glomerulonephritis (type II); Glomerulonephritis - membranoproliferative (type II); Mesangiocapillary glomerulonephritis (type II); Dense deposit disease; MPGN II
Symptoms:

Blood in the urine
Dark urine (smoke, cola, or tea colored)
Cloudy urine
Decrease in urine volume
Swelling of any part of the body
Changes in mental status
- decreased alertness
- decreased concentration

Note: Symptoms are variable.
Signs and tests:

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The results of a physical examination vary depending on the symptoms of the disorder. Edema (swelling) is common, along with signs of fluid overload such as abnormal sounds on auscultation of the heart and lungs. Blood pressure is often elevated.

These tests help confirm the diagnosis:

Abnormal urinalysis:
- white blood cells, urine
- red blood cells in urine
- protein, urine
- or other abnormalities.
Possible increase in BUN and creatinine, indicating decreased kidney function.
Possible decrease in serum complement levels indicating immune system involvement.
Possible presence of serum complement C3 nephritic factor.

A kidney biopsy confirms the diagnosis of membranoproliferative glomerulonephritis type II.