Analgesic nephropathy involves damage to one or both kidneys caused by overexposure to mixtures of medications, especially over-the-counter pain remedies (analgesics).
Phenacetin nephritis; Nephropathy - analgesic
Causes, incidence, and risk factors
Analgesic nephropathy involves damage within the internal structures of the kidney. It is caused by long-term use of
About 6 or more pills per day for 3 years increases the risk some for this problem. This frequently occurs as a result of self-medicating, often for some type of chronic pain.
Analgesic nephropathy occurs in about 4 out of 100,000 people, mostly women over 30. The rate has decreased significantly since phenacetin is no longer widely available in OTC preparations.
Risk factors include:
- Use of OTC analgesics containing more than one active ingredient
- Chronic headaches, painful menstrual periods, backache, or musculoskeletal pain
- Emotional or behavioral changes
- History of dependent behaviors including smoking,
alcoholism, and excessive use of tranquilizers
Review Date: 08/13/2009
Reviewed By: Parul Patel, MD, Private Practice specializing in Nephrology and Kidney and Pancreas Transplantation, Affiliated with California Pacific Medical Center, Department of Transplantation, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.