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Glucose-6-phosphate dehydrogenase deficiency

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Blood cells

Glucose-6-phosphate dehydrogenase deficiency

Alternative Names:

G-6-PD deficiency; Hemolytic anemia due to G6PD deficiency; Anemia - hemolytic due to G6PD deficiency
Symptoms:

Note: Severe hemolysis may cause hemoglobinuria (hemoglobin in the urine).
Signs and tests:

Anemia
Hemolysis
Reduced G-6-PD activity
Reticulocytosis following a hemolytic crisis

Tests include:

Elevated bilirubin levels
Elevated serum LDH
Low serum haptoglobin
Hemoglobin in the urine
Elevated absolute reticulocyte count
Low red blood cell count and hemoglobin
Heinz bodies present on examination of the peripheral blood smear using special stains
Methylene blue test
Methemoglobin reduction test

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