Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that causes blood clots to form in small blood vessels around the body, and leads to a low platelet count (
Causes, incidence, and risk factors
This disease may be caused by a lack of, or problems with, a certain enzyme (a type of protein) that is involved in blood clotting. These changes cause clotting to occur in an abnormal way.
- As the platelets clump together in these clots, fewer platelets are available in the blood in other parts of the body to help with clotting.
- This can lead to bleeding under the skin and purple-colored spots called
In some cases, the disorder is passed down through families (inherited) and patients are born with naturally low levels of this enzyme. This condition also may be related to:
Bone marrow transplantation
- Hematopoietic stem cell transplantation
Hormone replacement therapyand estrogens
- Medications (including ticlopidine, clopidogrel, guinine, and cyclosporine A)
Review Date: 02/28/2011
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.