Thrombotic thrombocytopenic purpura

Table of Contents

Alternative Names

TTP ADAMTS13


Symptoms
  • Bleeding into the skin or mucus membranes
  • Changes in consciousness
  • Confusion
  • Easy fatigue
  • Fever
  • Headache
  • Heart rate over 100 beats per minute
  • Pallor
  • Purplish spots in the skin produced by small bleeding vessels near the surface of the skin (purpura)
  • Shortness of breath
  • Speech changes
  • Weakness
  • Yellowish color to the skin (jaundice)

Signs and tests
  • ADAMTS 13 activity level
  • Bilirubin
  • Blood smear
  • CBC
  • Creatinine level
  • Lactate dehydrogenase (LDH) level
  • Mucus membrane biopsy
  • Platelet count
  • Urinalysis
  • Von Willebrand factor electropheresis


Review Date: 02/28/2011
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)