Multiple system atrophy

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Central nervous system

Multiple system atrophy

Definition:

Multiple system atrophy is a degenerative disorder characterized by the following:

Progressive damage to the nervous system, leading to low blood pressure when standing, difficulty urinating, and abnormal breathing during sleep
Muscle tremor and rigidity
Slow movement
Disrupted REM sleep patterns

Alternative Names:
Shy-Drager syndrome; Neurologic orthostatic hypotension; Shy-McGee-Drager syndrome; Parkinson's plus syndrome
Causes, incidence, and risk factors:

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Multiple system atrophy (MSA) is a rare degenerative condition. Its symptoms are similar to those of Parkinson's disease in that patients may move slowly, be tremulous, and have a shuffling gait.

However, in MSA there is more widespread neurologic damage and damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions). There is progressive degeneration of the nervous system, with damage to all parts of the nervous system, including the brain.

The cause is unknown. MSA develops gradually and is most often diagnosed in men older than 60.