Skin lesion of Histoplasmosis

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Histoplasmosis, disseminated in HIV patient

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Skin lesion of Histoplasmosis

• Skin lesion
  • Oral ulcer -- usually painless
  • Papule, pustule, or nodule -- may be found throughout the body
• Erythema nodosum -- may be seen in individuals with acute lung involvement
• Erythema multiforme (target lesions) -- may be seen in individuals with acute lung involvement

If the skin lesion is seen in the setting of disseminated histoplasmosis, a biopsy of the skin lesion may show the associated fungus. Other findings such as erythema nodosum and erythema multiforme are manifestations of the body's inflammatory reaction and usually do not have fungus in them.

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