Pemphigus vulgaris

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Pemphigus, vulgaris on the back Pemphigus, vulgaris - lesions in the mouth

Overview Symptoms Treatment Prevention

Pemphigus vulgaris

• Skin lesions which may be:
  • Recurrent or relapsing
  • Blistering, flaccid
  • Mouth or skin ulcers
  • Draining, oozing, crusting
  • Located on the mucous membrane of the mouth
  • Located on the scalp, trunk or other skin areas
  • Spreading to other skin areas
  • Peeling superficially or detaching easily

• Nikolsky's sign is positive -- when the surface of uninvolved skin is rubbed laterally with a cotton swab or finger, the skin separates easily.
• A skin lesion biopsy shows acantholysis.
• An examination of the biopsy tissue with immunofluorescence confirms pemphigus.
• The Tzanck test of a smear from the base of a blister shows acantholysis.

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