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Crigler-Najjar syndrome

Injury	Disease	Nutrition	Poison

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Liver anatomy

Crigler-Najjar syndrome

Alternative Names:

Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar)
Symptoms:

A family history of Crigler-Najjar syndrome
Yellow skin (jaundice) and eyes (icterus) that begins on the 2nd or 3rd day of life and progressively worsens
Jaundice that persists beyond 2 weeks of life without an obvious cause
Confusion and changes in thinking (resulting from brain toxicity of bilirubin)

Signs and tests:

Tests used to evaluate the liver function include:

Unconjugated bilirubin in blood (would be highly elevated)
Total bilirubin level (would be high)
Conjugated bilirubin (would be low to absent)
Liver biopsy, enzyme assay for low-absent Glucuronyl transferase activity
A family history of Crigler-Najjar syndrome

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