Gigantism

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Endocrine glands

Overview Symptoms Treatment Prevention

Gigantism

• Excessive growth during childhood.
• Frontal bossing and a prominent jaw
• Thickening of the facial features
• Disproportionately large hands and feet with thick fingers and toes
• Increased perspiration
• Weakness
• Secretion of breast milk
• Irregular menstruation
• Headache
• Delayed onset of puberty
• Double vision or difficulty with peripheral vision

• An increase in insulin growth factor-I (IGF-I) levels
• A failure to suppress serum growth hormone (GH) levels after an oral glucose challenge (maximum 75g)
• A CT or MRI scan of the head showing pituitary tumor
• High prolactin levels

Other hormone levels may be low due to damage to the pituitary, including thyroid hormone, testosterone (boys), estradiol (girls), or cortisol.

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