Hunter syndrome

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Overview

Symptoms

Treatment

Prevention

Hunter syndrome

Alternative Names:

Mucopolysaccharidosis type II, Iduronate sulfatase deficiency
Treatment:

There is no cure for Hunter syndrome. A specific treatment is being developed called enzyme replacement therapy. However, it is experimental and may not be able to prevent neurologic disease from getting worse. Individual problems should be addressed separately. Bone marrow transplant has been attempted for the early-onset form with variable results.

Expectations (prognosis):

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Life expectancy for the early-onset form (severe form) is 10-20 years. Life expectancy for the late-onset form (mild form) is 20-60 years.

Complications:

airway obstruction in late-onset form (mild form)
progressive mental deterioration in early-onset, severe form
progressive loss of activities of daily living in early-onset, severe form
progressive hearing loss in both mild and severe forms
progressive joint stiffness leading to contractures of joints in early-onset, severe form
carpal tunnel syndrome

Calling your health care provider:

Call your health care provider if you or your child manifest a group of these symptoms, or if you know you are a genetic carrier and are considering having children.