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Hallervorden-Spatz disease





Hallervorden-Spatz disease

Definition:

Hallervorden-Spatz disease is an inherited, degenerative disease that usually begins in childhood and involves progressive muscle rigidity, weakness, and movement disorder.


Causes, incidence, and risk factors:

Most cases of Hallervorde-Spatz are due to a mutation in the gene responsible for making a protein called pantothenate kinase 2. Patients with a mutated form of this gene accumulate iron in parts of the brain, especially the basal ganglia.




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