Chronic granulomatous disease

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Antibodies

Chronic granulomatous disease

Alternative Names:

CGD
Symptoms:

swollen lymph nodes in the neck that develop early in life and that persist or occur frequently
abscess formation in the lymph nodes of the neck that requires surgical drainage
frequent and difficult-to-clear skin infections
- chronic infection inside the nose
- impetigo
- abscesses
- furuncles
- impetiginized eczema (eczema complicated with an infection)
- perianal abscess
pneumonia
- occurs frequently
- is difficult to clear
persistent diarrhea
bone infections
joint infections

Signs and tests:

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Physical examination may show an enlarged liver (hepatomegaly), enlarged spleen (splenomegaly) and swelling of multiple lymph nodes all over the body (generalized adenopathy). Signs of osteomyelitis may appear, sometimes affecting multiple bones.

Tissue samples may be obtained for biopsy, which may show granulomas.

Other tests may include:

nitroblue tetrazolium test (NBT) to confirm the disease and detect carrier state in the mother
chemiluminescence assay to confirm the disease
CBC
ESR
chest X-ray
bone scan
liver scan