Hyperimmunoglobulin E syndrome

Table of Contents

Alternative Names

Job syndrome; Hyper IgE syndrome


Symptoms
  • Persistent skin abscesses and infection
  • Recurrent sinus infections
  • Eczema
  • Bone and tooth defects, including fractures and late shedding of baby teeth

Signs and tests

An eye exam may reveal signs of dry eye syndrome. A physical exam may show signs of osteomyelitis, curving of the spine (kyphoscoliosis), and recurrent sinus infections.

A chest x-ray may reveal lung abscesses.

Tests used to confirm a diagnosis include:

  • Absolute eosinophil count
  • CBC with blood differential
  • Serum globulin electrophoresis to look for high blood IgE levels

Other tests that may be done:

  • X-ray of the sinuses
  • X-ray of the bones
  • CT scan of the chest
  • Cultures of infected site
  • Special blood tests to investigate various components of the immune system


Review Date: 08/19/2009
Reviewed By: Andrew Schriber, MD, FCCP. Specialist in Pulmonary, Critical Care, and Sleep Medicine, Virtua Memorial Hospital, Mount Holly, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)