Hepatocerebral degeneration

Table of Contents

Definition

Hepatocerebral degeneration is a brain disorder that occurs in people with liver damage.


Alternative Names

Chronic acquired (Non-Wilsonian) hepatocerebral degeneration


Causes, incidence, and risk factors

This condition may occur in any case of acquired liver failure, including severe hepatitis.

Liver damage can lead to the build-up of ammonia and other toxic materials in the body. This happens when the liver doesn't work properly to break down and eliminate these chemicals. The toxic materials can damage brain tissue.

Specific areas of the brain, such as the basal ganglia, are more likely to be injured from liver failure. The basal ganglia help control movement. This condition is the "Non-Wilsonian" type. This means that the liver damage is not caused by copper deposits in the liver, which is a key feature of Wilson's disease.



Review Date: 07/07/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)