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Prader-Willi syndrome

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Hypotonia

Prader-Willi syndrome

Symptoms:

floppy newborn infant (hypotonic)
small for gestational age
undescended testicles in the male infant
delayed motor development
slow mental development
very small hands and feet in comparison to body
rapid weight gain with marked obesity
insatiable appetite, food craving
almond-shaped eyes
narrow bifrontal skull
morbid obesity
skeletal (limb) abnormalities
stria

Signs and tests:

hypotonia
hypomentia
hypogonadism
obesity

Other signs related to morbid obesity

hypoxia (chronic)
hypercapnia (chronic)
cor pulmonale
hyperinsulinism
abnormal glucose tolerance (see glucose tolerance test)
orthopedic, knee, and hip problems
failure to respond to luteinizing hormone releasing factor
skull and narrow bifrontal diameter

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