Symptoms may include:

• Almond-shaped eyes
• Delayed motor development
• Floppy newborn infant
• Insatiable appetite, food craving
• Irregular areas of skin that look like bands, stripes, or lines
• Narrow bifrontal skull
• Rapid weight gain
• Skeletal (limb) abnormalities
• Slow mental development
• Small for gestational age
• Undescended testicles in the male infant
• Very small hands and feet in comparison to body

Affected children have an intense craving for food and will do almost anything to get it. This results in uncontrollable weight gain and morbid obesity. Morbid obesity may lead to lung failure with low blood oxygen levels, right-sided heart failure, and death.

Signs of Prader-Willi syndrome may be seen at birth. Newborns with the condition are often small and very floppy. Male infants may have undescended testicles.

As the child grows older, laboratory tests may show signs related to morbid obesity, such as:

• Abnormal glucose tolerance
• Above normal level of insulin in the blood
• Excessive carbon dioxide levels
• Failure to respond to luteinizing hormone releasing factor
• Lack of oxygen supply

There may also be signs of right-sided heart failure and knee and hip problems.

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Prader Overview

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Prader Treatment

Review Date: 11/02/2009
Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)