Progeria

Injury Disease Nutrition Poison Symptoms Surgery Test Special Topic

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Coronary artery blockage

Overview Symptoms Treatment Prevention

Progeria

• Growth failure during the first year of life
• Narrow, wizened (shrunken or wrinkled) bird-like faces
• Baldness
• Loss of eyebrows and eyelashes
• Short stature
• Large head for size of face (macrocephaly )
• Soft spot (fontanelle) remains open
• Small jaw (micrognathia )
• Dry, scaly, thin skin
• Limited range of motion
• Teeth - delayed or absent formation

The signs include:

• Skin changes similar to that seen in scleroderma (the connective tissue becomes tough and hardened)
• Insulin-resistant diabetes (diabetes that does not respond readily to insulin injections)
• There may be early atherosclerosis of blood vessels leading to abnormal stress tests of the heart

Mutations in lamin A that cause progeria can be found using gene sequencing, but this is not usually needed for diagnosis.

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