Table of Contents
- Overview
- Symptoms
- Treatment
- Prevention
- Images
Hutchinson-Gilford syndrome
Symptoms
- Growth failure during the first year of life
- Narrow, shrunken or wrinkled face
Baldness - Loss of eyebrows and eyelashes
Short stature - Large head for size of face (
macrocephaly ) - Open soft spot (fontanelle)
- Small jaw (
micrognathia ) - Dry, scaly, thin skin
Limited range of motion Teeth - delayed or absent formation
Signs and tests
The signs include:
- Insulin-resistant
diabetes (diabetes that does not respond readily to insulin injections) - Skin changes similar to that seen in scleroderma (the connective tissue becomes tough and hardened)
Cardiac stress testing may reveal signs of early atherosclerosis of blood vessels.
Genetic testing can detect mutations in lamin A that cause progeria.
Images
Coronary artery blockage
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Progeria Treatment
Review Date: 08/26/2009
Reviewed By: Chad Haldeman-Englert, MD, Wake Forest University School of
Medicine, Department of Pediatrics, Section on Medical Genetics,
Winston-Salem, NC. Review provided by VeriMed Healthcare Network.
Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M.,
Inc.
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)
