• The first shot is given to infants before leaving the hospital. If the baby's mother carries the hepatitis B virus, the baby receives the first vaccine shortly after birth.
• The second shot is given between 1 and 2 months of age.
• The third shot is given at 6 months of age.

Infants who do not get the first shot until 4 to 8 weeks, will get the second shot at 4 months and the third shot at 6 to 16 months. Either way, the second and third shots are given along with other routine childhood immunizations.

Adolescents who have not been vaccinated should begin the three-shot hepatitis B vaccine series at the earliest possible date.

Adults or children who have not already received the vaccine should get the vaccine series if they:

• Are household contacts or sexual partners of persons known to be infected with hepatitis B
• Are men who have sex with other men
• Are on dialysis
• Have end-stage kidney disease, chronic liver disease, or HIV infection
• Have multiple sexual partners
• Use recreational, injectable drugs
• Will be having an organ transplant, bone marrow transplant, or chemotherapy

Adults can receive the hepatitis B vaccine only, or a vaccine called Twinrix that protects against both hepatitis A and B. Either series is given in 3 doses.

RISKS AND SIDE EFFECTS

Most infants who receive the hepatitis B vaccine have no side effects. Others may have minor problems, such as soreness and redness at the injection site or a mild fever. Serious problems are rare and are mainly due to allergic reactions to a part of the vaccine.

CONSIDERATIONS

If the child is ill with something more serious than a cold, the hepatitis B vaccine may be delayed.

Children who have had a severe allergic reaction to baker's yeast should not receive this vaccine.

A child who has a severe allergic reaction after receiving the vaccine should not get another hepatitis B vaccine.

CALL YOUR HEALTH CARE PROVIDER IF:

• You are not sure whether your child should get this vaccine
• Moderate or serious side effects appear after receiving the vaccine
• You have any questions or concerns

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Hepatitis B virus

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Review Date: 12/18/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)