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Neonatal cystic fibrosis screening



Infant blood sample
Infant blood sample


Neonatal cystic fibrosis screening

Alternative Names:

Cystic fibrosis screening - neonatal; Immunoreactive trypsinogen; IRT test
Normal Values:

The predicted value of a normal or negative test is an immunoreactive trypsinogen value less than 140 ng/dL.



Note: ng/dL = nanograms per deciliter


What abnormal results mean:

If your child's level of immunoreactive trypsinogen is greater than 140 ng/dL on the first screen, the test result is considered positive. If your child's level is 120 ng/dL on the second screen, the second test result is also considered positive.

Although these two test results indicate CF may exist, a sweat test with a positive result is necessary to confirm the diagnosis.


References:
Gross, SD, Boyle, CA, Botkin, JR, et al. Newborn Screening for Cystic Fibrosis:Evaluation of Benefits and Risks and Recommendations for State Newborn Screening Programs. MMWR. 2004;53(RR13);1-36.


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