Therapeutic drug levels

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

Testing involves taking multiple measurements of blood levels of a drug over time. The main purpose is to determine the effective drug dosages and to prevent toxicity. Drug level testing is especially important in people taking drugs such as:

• Procainamide or digoxin used to treat abnormal beating of the heart
• Dilantin or valproic acid used to treat seizures
• Gentamicin or amikacin, antibiotics used to treat infections

Often, these are drugs where the margin of safety between therapeutic levels and toxic levels is narrow. Testing may also be done to determine absorption, rate of metabolism, or interaction with other necessary drugs. Some drugs have more than one use.

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