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CPK isoenzymes



Blood test
Blood test


CPK isoenzymes

Alternative Names:

Creatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes
What abnormal results mean:


Higher-than-normal CPK-1 levels may occur with the following:

Higher-than-normal CPK-2 levels may occur with the following:
  • Heart attack
    • There is a significant rise in CPK-2 levels in the first 2 - 3 hours after a heart attack. This test is used to diagnose a heart attack.
    • The extent of the elevation depends on the severity of the heart attack. CPK levels may remain elevated up to 24 hours after a heart attack, and sometimes even longer.

  • Myocarditis (inflammation of the heart muscle usually due to a virus)
  • Electrical injuries
  • Trauma to the heart (for instance, from a car accident)
  • Heart defibrillation (purposeful shocking of the heart by medical personnel)
  • Open heart surgery

Higher-than-normal CPK-3 levels may occur with the following:

  • Crush injuries of skeletal muscle
  • Multiple intramuscular injections
  • Muscular dystrophy
  • Myositis (skeletal muscle inflammation)
  • Post-electromyography (a test of nerve and muscle function)
  • Recent seizures
  • Recent surgery
  • Rhabdomyolysis (skeletal muscle damage due to drugs or prolonged immobilization)
  • Strenuous exercise



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