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Febrile/cold agglutinins



Blood test
Blood test


Febrile/cold agglutinins

Alternative Names:

Cold agglutinins; Weil-Felix reaction; Widal's test
Normal Values:
  • Warm agglutinins: no agglutination in titers at or below 1:80
  • Cold agglutinins: no agglutination in titers at or below 1:16

What abnormal results mean:

Elevated levels of cold or warm agglutinins can cause hemolytic anemia. Some patients with moderately elevated levels will have no hemolysis and likely won't require therapy.



The presence of warm agglutinins may occur with:

The presence of cold agglutinins may occur with:

  • Infections, especially Mycoplasma pneumonia. Also after viral, staphylococcal, and malaria infection.
  • Cancer, including lymphoma and multiple myeloma
  • Systemic lupus erythematosus



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