Trypsinogen is a substance that is normally produced in the pancreas and released into the small intestine. Trypsinogen is converted to trypsin. Then it starts the process needed to break down proteins into their building blocks (called amino acids).

A test can be done to measure the amount of trypsinogen in your blood.

Serum trypsin; Trypsin-like immunoreactivity; Serum trypsinogen; Immunoreactive trypsin

A blood sample is needed. For information on how this is done, see: Venipuncture.

The blood is then tested in a laboratory.

There are no special preparations.

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

This test is done to detect diseases of the pancreas. However, it is no better than other tests, such as blood amylase or lipase for acute pancreatitis.

It is also ordered during routine newborn screening tests to check for cystic fibrosis.

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Trypsinogen test Results

Review Date: 02/04/2011
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program San Diego, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)