Normal values are 60% to 150% inhibition.

A lack (deficiency) of protein C can lead to excess clotting. These clots tend to form in veins, not arteries.

Protein C deficiency can be either passed down through families (inherited) or it can develop with other conditions. Liver disease, disseminated intravascular coagulation (DIC), warfarin (Coumadin), chronic antibiotic use, and chemotherapy can cause low protein C levels.

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Protein C Overview

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Protein C Risks

Review Date: 03/02/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)