The secretin stimulation test measures the ability of the pancreas to respond to a hormone called secretin. Secretin is produced by the small intestine when partially digested food has moved into the area from the stomach.

Pancreatic function test

A tube is inserted through the nose and into the stomach, then into the first part of the small intestine (duodenum). Secretin is given through a vein (intravenously). Then, over the next 1 - 2 hours, the contents of the material released from the pancreas into the duodenum are removed through the tube.

You will be asked to not eat or drink anything, including water, for 12 hours before the test.

You may experience a gagging sensation as the tube is inserted.

Secretin normally causes the pancreas to release a fluid containing digestive enzymes. These enzymes break down food and help the body absorb nutrients.

The secretin stimulation test is done to check the digestive function of the pancreas. People with diseases involving the pancreas may have abnormal pancreatic function. Such diseases include:

• Chronic pancreatitis
• Cystic fibrosis
• Pancreatic cancer

In these conditions, there may be a lack of digestive enzymes or other chemicals in the fluid that comes from the pancreas. This can reduce the body's ability to digest food and absorb nutrients.

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Secretin stimulation test

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Secretin stimulation test Results

Review Date: 11/23/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org)