Cold knife cone biopsy

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Female reproductive anatomy

Cold knife cone biopsy

Definition:

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A cold knife cone biopsy is a procedure to obtain a sample of abnormal tissue from the cervix for further examination. This procedure obtains a larger sample than that obtained by cervical punch biopsy or colposcopy-directed biopsy. An alternative procedure known as LEEP (loop electrocautery excisional procedure) uses electric current instead of a knife to remove the cervical tissue.

Alternative Names:
Cone biopsy; Biopsy - cone; Cervical conization
How the test is performed:

This is a surgical procedure, performed in the hospital under either intravenous sedation or general anesthesia, to diagnose and treat a precancerous change in the cervix.

A small cone-shaped sample of tissue is removed from the cervix and examined under a microscope for any signs of cancer. This biopsy may also serve as the treatment if all of the diseased tissue is removed.

How to prepare for the test:

As with any procedure performed under anesthesia, fasting for 6 to 8 hours is recommended. You must sign an informed consent form. The procedure is considered a same day procedure in which hospitalization is usually not necessary.

How the test will feel:

After the procedure, there may be some cramping or discomfort for a week or so. Avoid sexual intercourse, douching, and use of tampons for about 4 to 6 weeks. For 2 to 3 weeks after the procedure, you may have heavy, bloody, or a yellow-colored discharge.

Why the test is performed:

The test is done when results of a cervical biopsy indicate precancerous cells in the area or cervical cancer. A cold knife biopsy may also be done if the cervical biopsy has not revealed the cause of an abnormal Pap smear.