VesiclesFrom our partner site on skin cancer, SkinCancerConnection.com. Blisters Home Care: As a general rule, a physician should examine and diagnose any skin disease that includes vesicles. Nevertheless, over-the-counter treatments are available for certain conditions. Poison ivy may be soothed with calamine lotion and hydrocortisone cream. Cold sores might respond to application of local pain killers or docosanol. Call your health care provider if: advertisement Call your physician if any unexplained blisters appear on your skin. What to expect at your health care provider's office: Some vesicular eruptions can be diagnosed based entirely upon their history and appearance. In many cases, however, additional tests are needed. For example, the contents of a blister may be examined under the microscope or sent for bacterial or viral culture. In particularly difficult cases, a skin biopsy may be needed to make or confirm a diagnosis.
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