Gout - Causes

Other Medications. The list of drugs that cause hyperuricemia is long. In addition to diuretics and immunosuppressants, other agents that increase the risk for gout include the following:

• Pyrazinamide (used to treat tuberculosis).
• Aspirin. Low doses (not high doses) of aspirin reduce uric acid excretion and increase the chance for hyperuricemia. This may be a problem for older people who take baby aspirin (81 mg) to protect against heart disease. (High doses have the opposite effect.)
• Niacin.

Exposure to Lead. Chronic occupational exposure to lead is associated with build-up of uric acid and a high incidence of gout. A 2002 study suggested that persistent low-level exposure to lead may also increase the risk for gout.

Other Conditions. A number of other conditions can cause gout. They include:

• Leukemia
• Lymphoma
• Psoriasis

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