Headaches: Cluster - Risk Factors

Highlights	Risk Factors	Surgery
Introduction	Diagnosis	Resources
Cluster Headaches	Managing Cluster Headaches	References
Causes	Treatment
Prognosis	Medications

Risk Factors

Cluster headaches are, fortunately, rare, affecting less than 1% of the population.

Cluster Headaches in Men. Men are up to six to seven times more likely to suffer from cluster headaches than women are, although in recent decades the male to female ratio seems to be dropping. The peak age of onset in men is the twenties to early thirties.

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Cluster Headaches in Women. Studies of cluster headaches in women report that there are two ages of peak onset, the twenties and fifties. In some studies, the attacks in women were of shorter duration than in men but the duration of the episodes and length of remission were similar. Unlike with migraines, fluctuations in estrogen and other female hormones do not appear to influence the onset of attacks, although attacks may be less frequent during pregnancy.

Age

Cluster headaches typically start in the late twenties. In rare cases they begin in childhood, and about 10% of cases develop after age 60.

Lifestyle Factors

Cluster headaches appear to be more prevalent in those who are sociable, active, and responsible, and so a cluster headache is sometimes called "the executive headache." In one study, cluster headache patients tended to have more stressful jobs and be self-employed. Lifestyle factors, including smoking, alcohol abuse, and stress (in particular stressful work situations), appear to play a very strong role in this headache. Alcohol, in fact, can trigger an attack. A particularly high association exists between smoking and cluster headaches. Quitting smoking, however, is not associated with any fewer or less severe attacks.

Family History and Genetic Factors

Evidence for genetic factors has been weak, but there is a growing body of research suggesting a family history in about 5% to 10% of patients. Some evidence suggests that cluster headaches in women may be more likely to be genetically based, particularly when they first occur at younger ages.

High Iron Stores

Cluster headaches were also reported in two cousins with hereditary hemochromatosis, a disease characterized by the buildup of iron. Lowering iron levels in one of the cousins brought headache relief. Although this study does not prove that high iron levels cause cluster headaches, iron deposits in the brainstem may affect pain centers.

History of Migraine

A 2002 study reported that 26% of cluster headache sufferers also had a personal history of migraines and 33% had a family history of this headache. Most studies have reported that about 15% of patients have both kinds. (It should be noted, however, that the study noted here had a higher-than average number of women in the study. Also cluster headache is much less common than migraine.)