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Acquired platelet function defect

  • Definition

    Acquired platelet function defects are diseases or conditions that cause the blood elements needed for blood clotting (platelets) to not work properly. The term "acquired" means these diseases or conditions are not present at birth.

    Alternative Names

    Acquired qualitative platelet disorders; Acquired disorders of platelet function

    Causes, incidence, and risk factors

    With platelet disorders, there may be too many or too few platelets, or platelets that do not function well. Some conditions cause changes in both the number and function of platelets. Any platelet disorder affects blood clotting.

    These disorders can be present at birth (congenital), or they may develop later because of another disease or condition, or without a known cause. In many cases, the platelet count may be normal or even high, but there will be evidence of a bleeding disorder.

    Disorders that can cause problems in platelet function include:

    • Chronic myelogenous leukemia
    • Myelofibrosis
    • Polycythemia vera
    • Primary thrombocythemia

    Other causes include:

    • Kidney (renal) failure
    • Multiple myeloma
    • Medications such as aspirin, ibuprofen and other anti-inflammatory drugs, penicillins, phenothiazines, and prednisone (after long-term use)